Lymphoid malignancy and development, differentiation, and function of the lymphoreticular system.

patches of man, initiates and controls another lymphoid differ entiation pathway directed toward the plasma cell and immunoglobulin production. Thymus-dependent and bursa-dependent lymphocytic malignancies have been defined in the mouse and chicken, respectively, and are featured by abnormal Lymphoid differentiation beginning in one or the other central lymphoid organ. It is proposed that clinical lymphoid malignancies may also be usefully classified as either thymus system or immunoglobulin-producing system malignancies. In this view Hodgkin's